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. 2020 Dec 18;10(4):290. doi: 10.3390/jpm10040290

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of entrectinib and combination treatment on cell viability and toxicity. Impact of entrectinib treatment in combination with (A) trametinib, (C) abemaciclib, (E) everolimus on cell viability in triplicates in the indicated cell models measured by ATP-based survival assays upon 72 h drug exposure. Combination index (CI) based on the distinct drug combinations (B) trametinib, (D) abemaciclib, (F) everolimus were calculated as published [20]. CI values < 0.9 indicates synergistic, CI = 0.9–1.2 additive and CI > 1.2 antagonistic effects.