Table 1.
Histopathologic, molecular characteristics and next-generation sequencing.
| Case | Disease Status | Location | Histology | Gene-Fusion | Mutations | MGMT | Chromosomal Deletions | Molecular Findings | Cell Line |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 1st recurrence | right hemisphere | IHG | ROS/ARCN1 | PTEN | unmeth. | 10 | MAPK-activation | - |
| 2 | primary tumor | left occipital | gliosarcoma | EML4-NTRK3 | MRE11A (VUS) | unmeth. | CDKN2A/B | - | VBT247 |
| 2 | 3rd recurrence | left fronto-median | gliosarcoma | EML4-NTRK3 | INSR, NF2 | unmeth. | 5 p, 8 p, 20, 22, CDKN2A/B | AURKC, IGF1, TGFB3 overexpression | VBT363 |