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. 2020 Dec 21;12(12):3859. doi: 10.3390/cancers12123859

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Synergistic effect of RL1, TMZ, and TTFields. (a–e) All color coded GSCs according to RL1 IC₅₀ value showed a significant synergistic effect when combining RL1 with TMZ (colored lines), and an increased significant synergistic effect when adding TTFields to the combination. Under each figure, there is a small table with the multiplication fold values of RL1 and TMZ. The statistical test performed was one-way-ANOVA. The significance of the difference between groups was described as * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

Synergistic effect of RL1, TMZ, and TTFields. (a–e) All color coded GSCs according to RL1 IC₅₀ value showed a significant synergistic effect when combining RL1 with TMZ (colored lines), and an increased significant synergistic effect when adding TTFields to the combination. Under each figure, there is a small table with the multiplication fold values of RL1 and TMZ. The statistical test performed was one-way-ANOVA. The significance of the difference between groups was described as * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.