Skip to main content
. 2020 Dec 18;12(12):3823. doi: 10.3390/cancers12123823

Figure 1.

Figure 1

A fatty acid-binding protein (FABP) gene cluster at chromosome 8q21.13 is preferentially amplified in human metastatic prostate cancer (PCa). (A) Five FABP (FABP12, FABP4, FABP9, FABP8 and FABP5) genes are clustered on human chromosome 8 at 8q21.13. The left panel shows the chromosomal banding pattern of human chromosome 8 and the right panel provides physical distance between each FABP gene locus in millions of base pairs (M) of DNA. Chromosomal and gene mapping information was obtained from the NCBI (www.ncbi.nlm.nih.gov). (B) FABP gene amplification frequencies in tumor tissues from primary PCa cohorts. (C) FABP gene amplification frequencies in tumor tissues from metastatic PCa cohorts. (D) Comparison of mRNA levels for each FABP gene in the 8q21.13 amplicon between primary and metastatic PCa tissues. Analysis of FABP gene amplification and mRNA levels was carried out using human PCa patient datasets from cBioPortal (www.cbioportal.org). Error bars represent standard deviation. n denotes sample size; p, statistical significance level.