Table 2.
Plasma level of inflammatory cytokines according to FIB-4 score.
| Overall | FIB-4 Score | p | ||
|---|---|---|---|---|
| ≤3.25 | >3.25 | |||
| Pro-inflammatory | ||||
| IL-1β | 9.8 (5.0, 46.9) | 8.0 (4.6, 33.8) | 11.3 (5.2, 63.0) | 0.005 |
| IL-2 | 6.9 (0.50, 87.0) | 6.1 (0.5, 63.4) | 9.6 (0.5, 95.6) | 0.216 |
| IL-6 | 19.8 (6.8, 46.3) | 16.3 (4.8, 37.0) | 23.6 (10.2, 54.6) | 0.001 |
| IL-7 | 14.4 (6.2, 29.8) | 13.2 (5.3, 24.6) | 15.6 (6.4, 35.0) | 0.038 |
| IL-8 | 63.6 (32.5, 123.9) | 56.0 (31.7, 117.5) | 73.0 (34.5, 123.8) | 0.166 |
| IL-9 | 92.8 (39.4, 267.5) | 81.5 (32.7, 183.4) | 103.0 (50.0, 337.1) | 0.009 |
| IL-12 | 27.0 (1.9, 73.0) | 20.9 (1.5, 58.3) | 32.4 (3.7, 93.5) | 0.006 |
| IL-15 | 23.0 (5.3, 112.1) | 14.8 (5.3, 86.4) | 27.6 (5.3, 127.0) | 0.046 |
| IL-17 | 92.2 (11.1, 146.6) | 46.0 (9.7, 129.0) | 106.3 (13.8, 154.1) | 0.016 |
| G-CSF | 52.0 (27.2–82.0) | 44.5 (20.7, 89.7) | 54.8 (36.1, 80.1) | 0.278 |
| GM-CSF | 93.7 (0.3, 238.3) | 17.6 (0.2, 196.2) | 121.0 (2.2, 269.3) | <0.001 |
| IFN-γ | 41.0 (13.8, 72.4) | 29.9 (5.0, 65.7) | 47.0 (26.9, 75.2) | 0.002 |
| TNF-α | 46.0 (31.1, 70.0) | 40.8 (27.1, 70.3) | 50.5 (35.6, 68.3) | 0.015 |
| Anti-inflammatory | ||||
| IL-1rα | 324.5 (141.0, 755.4) | 288.9 (124.1, 722.8) | 338.1 (156.0, 801.7) | 0.210 |
| IL-4 | 5.6 (2.9, 61.0) | 5.1 (2.6, 11.2) | 5.9 (3.3, 80.0) | 0.008 |
| IL-5 | 10.0 (4.5, 22.0) | 10.6 (4.3, 20.0) | 10.0 (4.7, 23.0) | 0.632 |
| IL-10 | 9.9 (0.7, 61.0) | 7.4 (0.7, 40.8) | 11.8 (0.7, 71.6) | 0.001 |
| IL-13 | 8.4 (3.0, 32.0) | 6.6 (2.1, 20.9) | 10.1 (3.7, 34.1) | 0.006 |
| Chemoattractant | ||||
| IP-10 | 2390.3 (1331.0, 4196.2) | 2322.5 (1244.2, 4004.6) | 2565.7 (1492.8, 4208.3) | 0.335 |
| MCP-1 | 46.1 (14.9, 88.2) | 32.9 (14.2, 77.0) | 53.2 (16.0, 112.9) | 0.013 |
| MIP-1α | 4.9 (3.0, 37.0) | 5.1 (2.6, 19.2) | 4.8 (3.4, 42.3) | 0.102 |
| MIP-1β | 132.2 (84.1, 410.5) | 126.0 (87.6, 235.9) | 142.5 (80.4, 551.3) | 0.229 |
| RANTES | 19,871.0 (11759.0, 69279.6) | 19,700.5 (9854.2, 69279.6) | 19,979.5 (13163.8, 69279.6) | 0.881 |
| Growth factor | ||||
| Eotaxin | 182.7 (117.7, 294.1) | 179.1 (117.6, 263.7) | 193.0 (118.6, 324.2) | 0.126 |
| FGF-basic | 66.0 (9.8, 104.5) | 40.9 (4.35, 97.1) | 79.5 (30.6, 107.0) | 0.001 |
| PDGF-BB | 2840.7 (1266.9, 4561.9) | 2750.9 (1323.52, 4295.5) | 2924.1 (1231.3, 4616.9) | 0.978 |
| VEGF | 105.0 (27.05, 215.1) | 94.0 (7.6, 196.9) | 111.7 (47.0, 230.5) | 0.050 |
| Microbial Translocation | ||||
| sCD14 | 3.0 (2.2, 4.2) | 2.9 (2.2, 3.9) | 3.2 (2.2, 4.7) | 0.094 |
Data were presented as median and interquartile range (IQR), with μg/mL as the unit for sCD14 and pg/mL for all other cytokines. All the p-values were calculated by Mann–Whitney tests. Bold signifies statistical significance as p < 0.05.