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. 2020 Dec 17;13(12):472. doi: 10.3390/ph13120472

Figure 1.

Figure 1

Anxiolytic-like activity of Helichrysum stoechas Moench methanolic extract (HSE). (a,b) In the light dark box (LDB) test, HSE 100 reduced the time spent in the light chamber (a; one-way ANOVA post-hoc Tukey, F(4,35) = 14.52, * p < 0.05 vs. CTRL) and an increase in the number of transitions (b; one-way ANOVA post-hoc Tukey, F(4,35) = 15.55, *** p < 0.001 ** p < 0.01 vs. CTRL; °° p < 0.01, ° p < 0.05 vs. DIAZ) compared to mice with anxiety-like symptoms (CTRL) and diazepam (DIAZ). (c) HSE 100 reduced the number of buried marbles compared to CTRL (one-way ANOVA post-hoc Tukey, F (2,21) = 116.4, *** p < 0.001 ** p < 0.01 vs. CTRL). (d,e) In the novelty suppressed feeding test (NFST) HSE 100 increased the latency to feed (d; one-way ANOVA post-hoc Tukey F(2,21) = 42.36, * p < 0.05 vs. CTRL, °°° p < 0.001 vs. DIAZ) and reduced food consumption (e; Student’s t-test, * p < 0.05 vs. CTRL). (f) The food consumption was evaluated with the feeding behavior (two-way ANOVA post hoc Sidak, F(2,24) = 7.176, ** p < 0.01 vs. CTRL). The vertical bars represent ± SD of eight animals per group (n = 8).