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. 2020 Dec 17;13(12):472. doi: 10.3390/ph13120472

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Antinociceptive profile of Helichrysum stoechas Moench methanolic extract (HSE) against an (a) acute thermal stimulus (hot plate test) in comparison with control group (CTRL) and morphine (MORPH) (a, two-way ANOVA post-hoc Sidak, F(4,75) = 6.753, ** p < 0.01 * p < 0.05 vs. CTRL; °° p < 0.01, ° p < 0.05 vs. HSE 100) and against (b) mechanical stimulus (von Frey hairs) in a spared nerve injury (SNI) model (b; two-way ANOVA post-hoc Sidak, F (5,30) = 26.59, *** p < 0.001 vs. contra; °° p < 0.01 vs. HSE 100 ipsi; § p < 0.05 vs. CTRL). The vertical bars represent ± SD (n = 6).