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. 2020 Dec 17;12(12):3810. doi: 10.3390/cancers12123810

Figure 2.

Figure 2

Figure 2

The effect of irinotecan (IRI) and IRI with BGP-15 (IRI+BGP) treatment on muscle mass and fiber size. (A) Skeletal muscle masses of extensor digitorum longus (EDL), soleus (SOL), tibialis anterior (TA) and heart were measured post-mortem and are presented as both raw mass and as a muscle mass to body mass ratio. TA cross-sections were hematoxylin and eosin (H&E)-stained to assess the skeletal muscle histological fiber size with data presented as (B) muscle fiber cross-sectional area (CSA) percentage relative frequency distribution, (C) the mean group pooled muscle fiber CSA (of all fibers counted) and (D) the group pooled fiber size distribution. (E) Representative images of H&E-stained TA cross-sections show no evidence of muscle damage (e.g., centronucleated fibers and immune cell infiltrate). Scale bar = 50 µm; * = p < 0.05 compared to VEH, ^ = p < 0.05 compared to IRI; n = 6–8 for muscle weights; n = 4–6 for histology.