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. 2020 Dec 18;9(12):4092. doi: 10.3390/jcm9124092

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A–C): ATP quantification. Cellular ATP content was evaluated in HDF lines (A,B) and in mDANs (C) in baseline conditions, after 24-h starvation stress and after treatment with 10 µM CCCP for 24 h. Fold difference was calculated against WT in baseline conditions. Data were obtained from two independent experiments with samples measured in triplicate. Data are shown as mean ± SEM. Exploratory ANOVA was calculated. Figure A shows the data of HDF cell lines from PARK2 CNV duplication vs. deletion vs. wildtype healthy control separately, Figure B shows a combined analysis of PARK2 CNV deletion + duplication vs. wildtype ADHD + healthy to increase number of HDF cell lines and statistical power. Level of significance was set at p = 0.05. * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001.

(A–C): ATP quantification. Cellular ATP content was evaluated in HDF lines (A,B) and in mDANs (C) in baseline conditions, after 24-h starvation stress and after treatment with 10 µM CCCP for 24 h. Fold difference was calculated against WT in baseline conditions. Data were obtained from two independent experiments with samples measured in triplicate. Data are shown as mean ± SEM. Exploratory ANOVA was calculated. Figure A shows the data of HDF cell lines from PARK2 CNV duplication vs. deletion vs. wildtype healthy control separately, Figure B shows a combined analysis of PARK2 CNV deletion + duplication vs. wildtype ADHD + healthy to increase number of HDF cell lines and statistical power. Level of significance was set at p = 0.05. * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001.