Table 2.
Fractional anisotropy and apparent diffusion coefficient values.
| Variables | Patients | Controls | p-Value | Bulbar Onset | Spinal Onset | p-Value | UMN | Classic | p-Value | ΔALSFRS-R < 0.8 | ΔALSFRS-R ≥ 0.8 | p-Value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fractional Anisotropy, mean (SD) | ||||||||||||
| - corpus callosum | 0.40 (0.06) |
0.65 (0.04) |
<0.01 | 0.37 (0.07) |
0.41 (0.06) |
n.s. | 0.40 (0.07) |
0.40 (0.06) |
n.s. | 0.41 (0.06) |
0.39 (0.07) |
0.04 |
| - right corona radiata | 0.34 (0.03) |
0.61 (0.05) |
<0.01 | 0.35 (0.04) |
0.33 (0.03) |
0.05 | 0.32 (0.02) |
0.34 (0.03) |
n.s. | 0.34 (0.03) |
0.33 (0.04) |
n.s. |
| - left corona radiata | 0.34 (0.04) |
0.66 (0.07) |
<0.01 | 0.34 (0.05) |
0.34 (0.03) |
n.s. | 0.33 (0.02) |
0.34 (0.04) |
n.s. | 0.33 (0.03) |
0.34 (0.04) |
n.s. |
| - right cerebral peduncle | 0.34 (0.04) |
0.79 (0.04) |
<0.01 | 0.33 (0.05) |
0.34 (0.04) |
n.s. | 0.33 (0.05) |
0.34 (0.04) |
n.s. | 0.34 (0.04) |
0.34 (0.05) |
n.s. |
| - left cerebral peduncle | 0.40 (0.05) |
0.81 (0.04) |
<0.01 | 0.39 (0.03) |
0.40 (0.06) |
n.s. | 0.40 (0.03) |
0.40 (0.06) |
n.s. | 0.40 (0.06) |
0.40 (0.04) |
n.s. |
| - right corticospinal tract | 0.53 (0.04) |
0.72 (0.08) |
<0.01 | 0.52 (0.02) |
0.53 (0.04) |
n.s. | 0.54 (0.04) |
0.53 (0.04) |
n.s. | 0.54 (0.04) |
0.52 (0.04) |
n.s. |
| - left corticospinal tract | 0.55 (0.11) |
0.75 (0.05) |
<0.01 | 0.52 (0.02) |
0.56 (0.13) |
n.s. | 0.53 (0.03) |
0.56 (0.13) |
n.s. | 0.58 (0.16) |
0.52 (0.03) |
0.09 |
| - right cerebellar peduncle | 0.41 (0.05) |
0.66 (0.06) |
<0.01 | 0.40 (0.02) |
0.42 (0.06) |
n.s. | 0.41 (0.04) |
0.41 (0.05) |
n.s. | 0.41 (0.05) |
0.41 (0.05) |
n.s. |
| - left cerebellar peduncle | 0.43 (0.05) |
0.71 (0.10) |
<0.01 | 0.43 (0.01) |
0.43 (0.05) |
n.s. | 0.44 (0.03) |
0.43 (0.05) |
n.s. | 0.44 (0.06) |
0.43 (0.03) |
n.s. |
| Apparent diffusion coefficient, mean (SD) | ||||||||||||
| - corpus callosum | 1242 (271) |
825 (78) |
<0.01 | 1358 (303) |
1210 (258) |
n.s. | 1252 (291) |
1238 (270) |
n.s. | 1172 (214) |
1309 (308) |
0.02 |
| - right corona radiata | 692 (65) |
830 (70) |
<0.01 | 687 (82) |
694 (62) |
n.s. | 697 (82) |
691 (60) |
n.s. | 691 (71) |
695 (62) |
n.s. |
| - left corona radiata | 764 (120) |
739 (75) |
n.s. | 775 (140) |
762 (112) |
n.s. | 713 (60) |
781 (131) |
n.s. | 792 (136) |
740 (102) |
n.s. |
| - right cerebral peduncle | 1337 (240) |
742 (100) |
<0.01 | 1388 (263) |
1323 (236) |
n.s. | 1429 (274) |
1307 (224) |
n.s. | 1321 (246) |
1353 (240) |
n.s. |
| - left cerebral peduncle | 1070 (236) |
742 (124) |
<0.01 | 1051 (253) |
1076 (236) |
n.s. | 1141 (218) |
1047 (240) |
n.s. | 1057 (218) |
1083 (258) |
n.s. |
| - right corticospinal tract | 888 (67) |
777 (68) |
<0.01 | 898 (48) |
886 (72) |
n.s. | 896 (44) |
885 (73) |
n.s. | 889 (89) |
888 (38) |
n.s. |
| - left corticospinal tract | 863 (50) |
731 (77) |
<0.01 | 861 (26) |
865 (55) |
n.s. | 869 (43) |
862 (52) |
n.s. | 862 (62) |
866 (37) |
n.s. |
| - right cerebellar peduncle | 965 (243) |
729 (133) |
<0.01 | 886 (230) |
988 (246) |
n.s. | 1134 (375) |
910 (155) |
0.01 | 919 (148) |
1010 (306) |
n.s. |
| - left cerebellar peduncle | 791 (134) |
745 (69) |
n.s. | 777 (103) |
796 (143) |
n.s. | 767 (133) |
799 (135) |
n.s. | 805 (137) |
779 (134) |
n.s. |
SD: standard deviation; UMN: upper motoneuron; n.s.: not significant.