Figure 2.

Ciclesonide reduces tumor growth in a mouse model. The 2 × 10⁶ of breast cancer cells were injected into the mammary fat pads at nude mice. The inhibitory effect of ciclesonide on tumor growth in MDA-MB-231 tumor-bearing nude mice. (A) The effect of tumor growth with ciclesonide in the female nude mice containing breast cancer cells. The concentration of ciclesonide was 10 mg/kg. After 45 days, images were acquired. (B) Inhibitory effect of ciclesonide on the tumor weight. The nude mice were sacrificed on day 45, and tumors were weighed. Data from triplicate experiments are shown as the means ± SDs; *** p < 0.05 vs. the control. (C) The volumes of tumors from nude mice during the 45-day experimental period were comparable with those of tumors from control and ciclesonide-treated mice. Tumor volumes were calculated as follows: (width² × length)/2.