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. 2020 Dec 18;21(24):9694. doi: 10.3390/ijms21249694

Figure 3.

Figure 3

TCs/CD34+SCs in adipose tissue with iatrogenic insulin-amyloid type amyloidosis. (A): numerous TCs/CD34+SCs in adipose lobules are arranged between fibrous tracts. Double immunochemistry labelling for CD34 (brown) and αSMA (red). Insert: a nodule with haematoxylin staining. (B–H): amyloid deposits showing immunochemistry labelling for insulin (B) and amyloid P (C), Congo red positivity (D) with yellow-green birefringence under polarised light (E), and the colocalisation of insulin and collagen (I) ((F): insulin—red; (G): collagen (I)—green and (H): the colocation of both). (I): projections of TCs/CD34+SCs (brown) around folded amyloid deposits (asterisks). (J–L): TCs/CD34+SCs (brown, arrows) with projections around an amyloid deposit ((J), asterisk), adipocytes ((K), ad) and amyloid components in the adventitia (asterisk) of a vessel with double immunochemistry labelling for CD34 (brown) and αSMA (red). Bar: ((A) and insert): 160 µm; (B–H): 50 µm; (I–K): 20 µm; (L): 60 µm.