Table 1.
Baseline characteristics of hemodialysis patients with different phosphate binders used.
| Baseline Characteristics | Ferric Citrate Phosphate Binder (n = 8) | Calcium Carbonate Phosphate Binder (n = 46) | p-value |
|---|---|---|---|
| Age (years) | 55.8 ± 11.8 | 61.5 ± 10.9 | 0.178 |
| Male | 5 (62.5%) | 25 (54.3%) | 0.668 |
| Dialysis vintage (months) | 91.5 ± 80.45 | 84.11 ± 69.53 | 0.787 |
| Arteriovenous fistula | 7 (87.5%) | 44 (95.7%) | 0.353 |
| Cause of ESRD | |||
| Hypertension | 0 (0.0%) | 10 (21.7%) | 0.144 |
| Diabetes mellitus | 3 (37.5%) | 12 (26.1%) | 0.506 |
| Glomerulonephritis | 1 (12.5%) | 14 (30.4%) | 0.296 |
| Others * | 4 (50.0%) | 10 (21.7%) | 0.092 |
| Comorbidities | |||
| Diabetes mellitus | 3 (37.5%) | 15 (32.6%) | 0.786 |
| Hypertension | 7 (87.5%) | 38 (82.6%) | 0.732 |
| Dyslipidemia | 2 (25.0%) | 14 (30.4%) | 0.756 |
| Coronary artery disease | 1 (12.5%) | 3 (6.5%) | 0.551 |
| Cerebrovascular disease | 1 (12.5%) | 10 (21.7%) | 0.549 |
| Parathyroidectomy | 2 (25.0%) | 8 (17.4%) | 0.609 |
| Medications | |||
| Antiplatelet | 3 (37.5%) | 13 (28.3%) | 0.597 |
| Antihypertensive drugs | 5 (62.5%) | 25 (54.3%) | 0.668 |
| Diabetes treatment medications | 1 (12.5%) | 13 (28.3%) | 0.348 |
| Clinical laboratory data | |||
| Hemoglobin (g/dL) | 10.83 ± 1.38 | 10.89 ± 0.99 | 0.870 |
| Albumin (g/dl) | 3.87 ± 0.38 | 3.92 ± 0.34 | 0.672 |
| Alkaline phosphatase (IU/L) | 66.96 ± 15.35 | 76.25 ± 26.98 | 0.350 |
| Ion calcium (mg/dL) | 61.5 ± 10.94 | 71.06 ± 28.64 | 0.359 |
| Phosphate (mg/dL) | 5.13 ± 0.75 | 6.88 ± 8.68 | 0.575 |
| Parathyroid hormone (pg/mL) | 403.15 ± 206.76 | 283.16 ± 277.95 | 0.250 |
| Aluminum (ng/mL) | 13.25 ± 5.44 | 13.28 ± 6.47 | 0.991 |
| Magnesium (mg/dL) | 2.66 ± 0.42 | 8.44 ± 21.54 | 0.455 |
| Single pool Kt/V | 1.44 ± 0.15 | 1.53 ± 0.24 | 0.298 |
| Dietary intake (serving/day) | |||
| Meat | 0.7 ± 0.38 | 0.8 ± 0.54 | 0.760 |
| Vegetable | 1.3 ± 0.52 | 1.3 ± 0.60 | 0.852 |
| Fruit | 0.9 ± 0.62 | 1.1 ± 0.89 | 0.903 |
| Bristol stool scale | 4.5 ± 1.60 | 3.74 ± 1.82 | 0.273 |
* Other causes of end-stage renal disease include polycystic kidney disease, tumor, systemic lupus erythematosus, gout, and interstitial nephritis. Abbreviation: ESRD, end-stage renal disease.