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. 2020 Dec 18;12(12):3821. doi: 10.3390/cancers12123821

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Loss of GRP78 is associated with worse clinical outcome. (A) Kaplan–Meier plots of disease-free survival for low and high staining of IGFBP-3 in GRP78-negative tumours (n = 26; p = 0.134). (B) Representative images of GRP78 and IGFBP-3 IHC staining. (C) The overall survival of breast cancer patients was analysed in the METABRIC database in GRP78-negative tumours based on IGFBP-3 gene expression profile (n = 83; p = 0.003). Statistically significant differences were determined by two-sided log-rank test.