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The human pyrin and hematopoietic interferon-inducible nuclear (HIN) domain (PYHIN) protein family. Schematic organization of human PYHIN proteins. Each PYHIN family member possesses an N-terminal pyrin domain (PYD) and one or more HIN domains, classified as HIN A, HIN B and HIN C. With the exception of AIM2, all PYHIN proteins harbor at least one nuclear localization signal (NLS).
