Table 1.
Passive membrane properties and normalized ion current amplitude (current response evoked by the +50 mV pulse) of gastric fundus SMCs in the different conditions.
| Cm (pF) | Gm (pS) | RMP (mV) | IK (pA/pF) | ICa (pA/pF) | |
|---|---|---|---|---|---|
| CTRL | 13.5 ± 1.8 | 0.009 ± 0.002 | −47.2 ± 5.0 | 17.1 ± 3.7 | −20.3 ± 6.0 |
| (n = 52) | (n = 52) | (n = 50) | (n = 30) | (n = 20) | |
| ADPN | 24.7 ± 2.2 * | 0.0175 ± 0.002 | −59.4 ± 3.9 * | 23.9 ± 2.1 * | −10.1 ± 2 * |
| (n = 17) | (n = 16) | (n = 16) | (n = 9) | (n = 7) | |
| L-NNA | 12.3 ± 3.9 # | 0.0072 ± 0.001 | −47.0 ± 5.1 # | 8.3 ± 2.9 *,# | −24.9 ± 4.1 # |
| (n = 18) | (n = 18) | (n = 17) | (n = 10) | (n = 7) | |
| L-NNA + ADPN | 10.9 ± 3.1 # | 0.0078 ± 0.001 | −46.6 ± 4.3 # | 7.8 ± 1.8 *,# | −10.0 ± 2.3 *,§ |
| (n = 18) | (n = 18) | (n = 17) | (n = 10) | (n = 7) | |
| DORS | 9.5 ± 6.7 # | 0.005 ± 0.001 | −39.2 ± 5.9 # | 17.6 ± 3.0 # | −27.3 ± 4.1 # |
| (n = 16) | (n = 13) | (n = 14) | (n = 7) | (n = 6) | |
| DORS + ADPN | 8.5 ± 2.4 # | 0.007 ± 0.002 | −35.7 ± 4.9 # | 17.8 ± 2.8 # | −25 ± 2.3 # |
| (n = 16) | (n = 13) | (n = 14) | (n = 7) | (n = 6) |
One-way ANOVA with Bonferroni’s post hoc test was used for multiple comparisons. *, p < 0.05 significant difference from CTRL; #, p < 0.05 significant difference from ADPN; §, p < 0.05 significant difference from L-NNA. n represents the number of SMCs used (10 mice). Values are means ± SD.