Figure 6.

Effects of N6NH₂ and its analogs on biofilm in mice: (A) effects of N6NH₂ and its analogs on retained bacteria in early biofilms; (B) effects of N6NH₂ and its analogs on biofilm formation in mouse; (C) effects of N6NH₂ and its analogs on skin injuries induced by A. veronii ACCC61732 biofilm. Catheters with A. veronii ACCC61732 biofilm were incubated in the skin of the backs of mice treated with N6NH₂ and its analogs (5 μmol/kg). Skins were harvested and detected at 7 d post infection. (Top) Microscope magnification 100 times; (Bottom) microscope magnification 200 times. The analyses were measured by one-way ANOVA, with Duncan’s multiple comparisons test. A p-value of <0.05 was considered significant. (*) Indicates the significance between control and treatment groups. * p < 0.05; ** p < 0.01, *** p < 0.001, **** p < 0.0001.