Table 2.
MIC values of N6NH2 and its analogs.
| Species and Strains | MIC | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N6NH2 | DN6NH2 | N6PNH2 | V112N6NH2 | Guo-N6NH2 | CIP | |||||||
| μg/mL | μM | μg/mL | μM | μg/mL | μM | μg/mL | μM | μg/mL | μM | μg/mL | μM | |
| Gram-negative bacteria | ||||||||||||
| Aeromonas veronii ACCC61732 a | 4 | 1.61 | 4 | 1.62 | 16 | 6.62 | 16 | 6.25 | 8 | 3.04 | 0.125 | 0.38 |
| A. veronii X-1-06909 b | 32 | 12.9 | 32 | 12.93 | 64 | 26.49 | 32 | 12.51 | 16 | 6.08 | 0.25 | 0.75 |
| A. veronii CL0901 b | 16 | 6.46 | 32 | 12.93 | 64 | 26.49 | 32 | 12.51 | 16 | 6.08 | 0.0625 | 0.19 |
| A. veronii ATCC35624 | 8 | 3.23 | 64 | 25.86 | 64 | 26.49 | 16 | 6.25 | 32 | 12.16 | <0.0625 | <0.19 |
| Escherichia coli CVCC195 | 4 | 1.61 | 8 | 3.23 | 8 | 3.31 | 8 | 3.13 | 4 | 1.52 | <0.0625 | <0.19 |
| E. coli CVCC1515 | 2 | 0.81 | 4 | 1.62 | 4 | 1.66 | 4 | 1.56 | 2 | 0.76 | <0.0625 | <0.19 |
| E. coli CVCC25922 | 4 | 1.61 | 8 | 3.23 | 8 | 3.31 | 8 | 3.13 | 4 | 1.52 | <0.0625 | <0.19 |
| E. coli CVCCO157 | 4 | 1.61 | 4 | 1.62 | 8 | 3.31 | 8 | 3.13 | 4 | 1.52 | <0.0625 | <0.19 |
| Salmonella typhimurium ATCC14028 | 4 | 1.61 | 8 | 3.23 | 16 | 6.62 | 16 | 6.25 | 4 | 1.52 | 0.0625 | 0.19 |
| S. pullorum CVCC1809 | 4 | 1.61 | 8 | 3.23 | 8 | 3.31 | 8 | 3.13 | 4 | 1.52 | <0.0625 | <0.19 |
| S. pullorum CVCC1789 | 8 | 3.23 | 16 | 6.46 | 16 | 6.62 | 16 | 6.25 | 8 | 3.04 | <0.0625 | <0.19 |
| S. pullorum CVCC533 | 4 | 1.61 | 16 | 6.46 | 32 | 13.25 | 16 | 6.25 | 8 | 3.04 | <0.0625 | <0.19 |
| S. enteritidis CVCC3377 | 2 | 0.81 | 2 | 0.81 | 2 | 0.83 | 2 | 0.78 | 2 | 0.76 | <0.0625 | <0.19 |
| Pseudomonas aeruginosa CICC21630 | 64 | 25.8 | 8 | 3.23 | >64 | >26.49 | 32 | 12.5 | >64 | >24.3 | 0.125 | 0.38 |
| Gram-positive bacteria | ||||||||||||
| Staphylococcus aureus ATCC43300 | 16 | 6.46 | 4 | 1.62 | >64 | >26.49 | 32 | 12.5 | 16 | 6.08 | 0.25 | 0.75 |
| S. aureus ATCC546 | 16 | 6.46 | 16 | 6.46 | >64 | >26.49 | 16 | 6.25 | 16 | 6.08 | 0.125 | 0.38 |
| S. aureus ATCC25923 | 32 | 12.9 | 8 | 3.23 | >64 | >26.49 | 32 | 12.5 | 32 | 12.16 | 0.125 | 0.38 |
| S. hyicus NCTC10350 | 32 | 12.9 | 8 | 3.23 | >128 | >52.98 | 64 | 25.01 | 64 | 24.32 | 0.125 | 0.38 |
| S. hyicus 437-2 c | 32 | 12.9 | 8 | 3.23 | >64 | >26.49 | 32 | 12.5 | 32 | 12.16 | 8 | 24.14 |
| Fungus | ||||||||||||
| Candida albicans CMCC98001 | >128 | >52 | 128 | 51.72 | >128 | >52.98 | >128 | >50.02 | >128 | >48.6 | >128 | >386.3 |
Note: a Clinical isolated strain from the liver tissue of California sea bass in the Nankou experimental base of the Chinese Academy of Agricultural Sciences. The MDR A. veronii ACCC61732 strain is resistant to imipenem, meropenem, tetracycline, and trimethoprim, and it was highly sensitive to quinolone antibiotics such as ciprofloxacin, norfloxacin, and oxaliplatin. Data are representative of three independent experiments. b A. veronii X-1-06909 and A. veronii CL0901 were kindly provided by the Beijing Fisheries Research Institute. c Clinical isolated strain of Tianjin pig farm. ACCC, Agricultural Culture Collection of China; CVCC, China Veterinary Culture Collection Center; ATCC, American Type Culture Collection; CICC, China Center of Industrial Culture Collection; NCTC, National Collection of Type Cultures; CMCC, National Center for Medical Culture Collection.