Table 1.
Classification of matrix metalloproteinases according with their structure and on the basis of their specificity for extracellular matrix components [6,7].
| Feature | Subgroup | Description | MMPs |
|---|---|---|---|
| Structure | Minimal domain MMPs | Secreted | MMP-7, MMP-26 |
| Simple Hemopexin domain-containing MMPs | Secreted | MMP-1, -3, -8, 10, -12, -13, -18, -19, -22, -20, 27 | |
| Gelating binding MMPs | Secreted | MMP-2, MMP-9 | |
| Furin-activated MMPs | Secreted | MMP-11, MMP-28 | |
| Vitronectin-like insert MMPs | Secreted | MMP-21 | |
| Transmembrane MMPs (with cytoplasmic domain) | Membrane-type MMPs | TM: MMP-14, -15, -16, -24. | |
| glycosylphosphatidylinositol (GPI)-anchored MMPs | Membrane-type MMPs | MMP-17, MMP-25 | |
| Type II transmembrane MMPs (cysteine array and immunoglobulin-like domains) | Membrane-type MMPs | MMP-23 | |
| Substrate | Collagenases (1–4) | Substrates: Col II, II, III, VIII, X, gelatins, aggrecan, entactin | MMP-1, -8,-13, -18 |
| Gelatinases (A and B) | Substrates: gelatins, collagens I, IV, V, VII, X, XI, fibronectin elastin, laminin, vitronectin, proMMPs-9 and 13 | MMP-2, MMP-9 | |
| Stromelysins (1–3) | Substrates: proteoglycans, laminin, gelatins, fibronectin, entactin, collagens III, IV, V, IX, X, XI, proMMPs 1, 8, 9 and 13, vitronectin, α 1-proteinase inhibitor | MMP-3, -10, -11 | |
| Matrilysin | Substrates: proteoglycans, laminin, fibronectin, gelatins, entactin, collagen IV, elastin, tenascin | MMP-7, MMP-26 | |
| Membrane-type MMPs (MT-MMP-1, -3, -4) | Substrates: col I, II, III, gelatins, fibronectin, laminin, proteoglycans, proMMP-2 and 13 | MMP-14,-15, -16, -17, -24, -25 |