Table 4.
Univariable Cox regression composite of heart failure hospitalization, unscheduled AR intervention, and cardiovascular death.
| Crude HR (95% CI) | p-Value | |
|---|---|---|
| Age | 1.04 (1.03–1.60) | <0.001 |
| Female Sex | 1.69 (1.09–2.61) | 0.018 |
| Body Mass Index (kg/m2) | 1.01 (0.96–1.06) | 0.776 |
| Hypertension | 2.10 (1.26–3.49) | 0.004 |
| Atrial Fibrillation | 1.82 (1.16–2.86) | 0.009 |
| Diabetes | 1.86 (1.07–3.22) | 0.027 |
| Hyperlipidemia | 1.56 (0.99–2.43) | 0.051 |
| Coronary Artery Disease | 2.36 (1.50–3.69) | <0.001 |
| Previous stroke | 0.76 (0.19–3.11) | 0.704 |
| Hematocrit | 0.91 (0.87–0.95) | <0.001 |
| eGFR (mL/min/1.73 m2) | 0.98 (0.97–0.99) | <0.001 |
| Bicuspid aortic valve | 0.12 (0.03–0.50) | 0.003 |
| CMR LVEDV/BSA (1-SD, mL/m2) | 1.03 (0.812–1.30) | 0.830 |
| CMR RVEDV/BSA (1-SD, ml/m2) | 1.11 (0.89–1.39) | 0.353 |
| CMR LVEF (%) | 0.97 (0.95–0.99) | <0.001 |
| CMR RVEF (%) | 0.97 (0.96–0.99) | <0.001 |
| CMR RegF (%) | 1.02 (1.01–1.03) | 0.004 |
| CMR RegV (mL) | 1.01 (0.99–1.02) | 0.273 |
eGFR indicates estimated glomerular filtration rate; CMR, cardiovascular magnetic resonance imaging; RegF, Regurgitation Fraction; RegV, regurgitation volume.