Table 1.
Comparison of characteristics and outcomes of patients receiving appropriate antimicrobial therapy and those receiving inappropriate antimicrobial therapy.
| Variable | Appropriate Antimicrobial Therapy (n = 33) |
Inappropriate Antimicrobial Therapy (n = 74) |
p Value |
|---|---|---|---|
| Demographics | |||
| Age, years, mean ± SD | 72.06 ± 15.33 | 75.69 ± 14.02 | 0.232 |
| Male sex | 19 (57.6) | 33 (44.6) | 0.215 |
| LOS before CRKP isolation, days, mean ± SD | 24.73 ± 34.03 | 25.07 ± 35.45 | 0.963 |
| Carbapenemase-producing CRKP | 14 (42.4) | 30 (40.5) | 0.855 |
| Previous hospitalization 1 | 15 (45.5) | 40 (54.1) | 0.411 |
| Comorbidities | |||
| Diabetes mellitus | 17 (51.5) | 41 (55.4) | 0.709 |
| COPD | 7 (21.2) | 12 (16.2) | 0.532 |
| Heart failure | 12 (36.4) | 20 (27.0) | 0.330 |
| Cerebrovascular disease | 8 (24.2) | 29 (39.2) | 0.133 |
| Chronic kidney disease 2 | 20 (60.6) | 42 (56.8) | 0.710 |
| Liver cirrhosis | 2 (6.1) | 3 (4.1) | 0.643 |
| Malignancy | 8 (24.2) | 27 (36.5) | 0.212 |
| Immunocompromised state | 4 (12.1) | 8 (10.8) | 0.843 |
| Charlson Comorbidity Index, mean ± SD | 3.97 ± 2.38 | 4.15 ± 2.88 | 0.755 |
| Indwelling urinary catheter | 22 (66.7) | 54 (73.0) | 0.507 |
| Nasogastric tube | 21 (63.6) | 50 (67.6) | 0.691 |
| Surgical drainage | 2 (7.5) | 7 (9.5) | 0.559 |
| Mechanically ventilated at isolation | 9 (27.3) | 13 (17.6) | 0.251 |
| Renal dialysis at isolation | 6 (18.2) | 5 (6.8) | 0.072 |
| APACHE II score, mean ± SD | 19.45 ± 10.08 | 20.11 ± 8.96 | 0.738 |
| Shock | 2 (6.1) | 5 (6.8) | 0.893 |
| LOS after CRKP isolation, days, mean ± SD | 23.17 ± 24.12 | 23.59 ± 25.43 | 0.491 |
| 14-day mortality | 3 (9.1) | 12 (16.2) | 0.327 |
| 28-day mortality | 9 (27.3) | 18 (24.3) | 0.746 |
| all-cause mortality | 9 (27.3) | 21 (28.4) | 0.906 |
Data are expressed as No. (%) unless otherwise specified. Abbreviations: SD, standard deviation; LOS, length of hospital stay; COPD, chronic obstructive pulmonary disease; APACHE, Acute Physiology and Chronic Health Evaluation. 1 During the 3 months preceding infection onset. 2 Defined as estimated glomerular filtration rate ≤ 60 mL/min/1.73 m2.