Table 2.
Comparison of characteristics of 14-day survivors and 14-day non-survivors with carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria.
| Variable | 14-Day Survivors (n = 92) |
14-Day Non-Survivors (n = 15) |
p Value |
|---|---|---|---|
| Demographics | |||
| Age, years, mean ± SD | 74.58 ± 14.73 | 74.53 ± 13.16 | 0.992 |
| Male sex | 44 (47.8) | 8 (53.3) | 0.692 |
| LOS before CRKP isolation, days, mean ± SD | 24.77 ± 35.32 | 26.13 ± 32.99 | 0.889 |
| Carbapenemase-producing CRKP | 38 (41.3) | 6 (40.0) | 0.924 |
| Previous hospitalization 1 | 47 (51.1) | 8 (53.3) | 0.872 |
| Comorbidities | |||
| Diabetes mellitus | 46 (50.0) | 12 (80.0) | 0.031 |
| COPD | 15 (16.3) | 4 (26.7) | 0.330 |
| Heart failure | 25 (27.2) | 7 (46.7) | 0.126 |
| Cerebrovascular disease | 31 (33.7) | 6 (40.0) | 0.634 |
| Chronic kidney disease 2 | 53 (57.6) | 9 (60.0) | 0.862 |
| Liver cirrhosis | 4 (4.3) | 1 (6.7) | 0.537 |
| Malignancy | 30 (32.6) | 5 (33.3) | 0.956 |
| Immunocompromised state | 10 (10.9) | 2 (13.3) | 0.779 |
| Charlson Comorbidity Index, mean ± SD | 3.90 ± 2.67 | 5.27 ± 2.87 | 0.072 |
| Indwelling urinary catheter | 64 (69.6) | 12 (80.0) | 0.409 |
| Nasogastric tube | 59 (64.1) | 12 (80.0) | 0.228 |
| Surgical drainage | 8 (8.7) | 1 (6.7) | 0.793 |
| Mechanically ventilated at isolation | 19 (20.7) | 3 (20.0) | 0.954 |
| Renal dialysis at isolation | 10 (10.9) | 1 (6.7) | 0.619 |
| APACHE II score, mean ± SD | 18.27 ± 8.13 | 29.93 ± 9.83 | <0.001 |
| Appropriate antimicrobial therapy | 30 (32.6) | 3 (20.0) | 0.327 |
| Shock | 4 (4.3) | 3 (20.0) | 0.023 |
Data are expressed as No. (%) unless otherwise specified. Abbreviations: SD, standard deviation; LOS, length of hospital stay; COPD, chronic obstructive pulmonary disease; APACHE, Acute Physiology and Chronic Health Evaluation. 1 During the 3 months preceding infection onset. 2 Defined as estimated glomerular filtration rate ≤ 60 mL/min/1.73 m2.