Table 2.
Summary of quality assessment according to the GRADE system.
| Study (Publication Year) | Initial Rating | Risk of Bias | Imprecision | Inconsistency | Indirectness | Publication Bias | Large Magnitude of Effect | Quality of Evidence |
|---|---|---|---|---|---|---|---|---|
| ICI monotherapy | ||||||||
| Bjornhart B et al (2019) [7] | Low | Not serious | Not serious | Not serious | Not serious | Not serious | Not large | Low |
| Dudnik E et al (2016) [8] | Low | Not serious | Serious | Not serious | Not serious | Not serious | Not large | Very low |
| Gauvain C et al (2018) [9] | Low | Not serious | Not serious | Not serious | Not serious | Not serious | Not large | Low |
| Goldberg SB et al (2016) [10] | High | Not serious | Not serious | Not serious | Not serious | Not serious | Not large | High |
| Hendriks LEL et al (2019) [24] | Low | Not serious | Serious | Not serious | Serious | Not serious | Not large | Very low |
| Kim R et al (2019) [11] | Low | Not serious | Not serious | Serious | Not serious | Not serious | Not large | Very low |
| Song P et al (2019) [12] | Low | Not serious | Serious | Not serious | Not serious | Not serious | Not large | Very low |
| ICI combined with chemotherapy | ||||||||
| Afzal MZ et al (2018) [25] | Low | Not serious | Serious | Not serious | Not serious | Not serious | Not large | Very low |
| ICI combined with radiotherapy | ||||||||
| Ahmed KA et al (2017) [26] | Low | Serious | Not serious | Not serious | Not serious | Not serious | Not large | Very low |
| Schapira E et al (2018) [27] | Low | Serious | Not serious | Not serious | Not serious | Not serious | Not large | Very low |
| Shepard MJ et al (2019) [13] | Low | Not serious | Not serious | Not serious | Not serious | Not serious | Not large | Low |
| Singh C et al (2019) [14] | Low | Serious | Not serious | Not serious | Not serious | Not serious | Large | Low |