Table 1.
Histologic scores for lungs of DEP-induced mice.
| Group | Naive Control | Vehicle Control | DEP 25 |
DEP 50 |
DEP 100 |
|
|---|---|---|---|---|---|---|
| Accumulation of black particle-laden | Minimal | 0 | 0 | 1 | 0 | 0 |
| alveolar macrophages and black | Mild | 0 | 0 | 4 | 2 | 0 |
| particles in alveolar lumen | Moderate | 0 | 0 | 0 | 3 | 2 |
| Marked | 0 | 0 | 0 | 0 | 3 | |
| Mean ± SD | 0 | 0 | 1.8 ± 0.45 ## | 2.6 ± 0.55 ## | 3.6 ± 0.55 ## | |
| Inflammatory cell infiltration, | Minimal | 0 | 0 | 4 | 3 | 0 |
| peribronchiolar/perivascular/interstitial | Mild | 0 | 0 | 0 | 2 | 5 |
| Mean ± SD | 0 | 0 | 0.8 ± 0.45 # | 1.4 ± 0.55 ## | 2 ± 0.0 ## |
Data are means ± SD for five mice per group. DEP, diesel exhaust particulate. # p < 0.05 or ## p < 0.001 vs. vehicle control.