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. 2020 Dec 21;21(24):9769. doi: 10.3390/ijms21249769

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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TLR3 promotes melanosome transfer. TLR3 stimulation reduces de novo melanin synthesis by suppressing the expression of MITF, TYRP1, and DCT. On the other hand, TLR3 stimulation promotes extracellular release of melanosomes through Rab27A induction. Rab27A on melanosomes binds to the actin-dependent motor protein myosin Va via Slac2-a and promotes actin transport toward the cell periphery near the cell membrane by forming a tripartite complex. Abbreviations: TLR: toll-like receptor; MITF: microphthalmia-associated transcription factor; TYRP1: tyrosinase-related protein 1; DCT: dopachrome tautomerase.