Table 2.
Effect of innate immune stimulation on melanin transfer from melanocyte to keratinocytes.
| Action | TLR2 | TLR3 | ||||
|---|---|---|---|---|---|---|
| Melanin Transfer | in MC | Effect | N.E. | Promote | ||
| Targeted molecule | Rab27A | |||||
| Ref. | [49] | |||||
| Melanin Release | from MC | Effect | Promote | Promote | ||
| Targeted molecule | Rab11A | Rab11A | ||||
| Ref. | [54] | [54] | ||||
| Melanin Uptake | by KC | Effect | N.E. | Promote | ||
| Targeted genes | PAR-2 | RHOA | CDC42 | |||
| Ref. | [55] | |||||
| Melanin Degradation | in KC | Effect | N.E. | Promote | ||
| Targeted molecule | Autophagy activation | |||||
| Ref. | [56] | |||||
MC; melanocytes, KC; keratinocytes, TLR; toll-like receptor, PAR-2; protease- activated receptor-2, RHOA; Ras homolog family member A, CDC42; cell division control protein 42 homolog, N.E.; not examined, Ref.; References.