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. 2020 Dec 21;12(12):1476. doi: 10.3390/v12121476

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Variation in the BKPyV LTag protein sequence. BKPyV subtype specific variation and amino acid exchanges not related to a certain BKPyV subtype (i.e., BKPyV variants) in the large tumor antigen (LTag) protein sequence were identified (upper panel); number of laboratories that deposited full-length BKPyV genome or partial LTag sequences from BKPyV-variants (lower panel). Schematic drawing of the respective domains in LTag and small T antigen (sTag; according to DeCaprio and Garcea [44]) are indicated below the diagram (DnaJ homology region (DnaJ), retinoblastoma protein binding domain (pRb), origin of DNA replication binding domain (ori), host range domain (HR)). Of note, the amino-terminal part including the DnaJ homology domain is identical for sTag and LTag, whereas the carboxyterminal domains indicated are specific for sTag or LTag.