Table 2.
Univariate and Multivariate Survival Analyses of OS in Patients with Colorectal Cancer
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age | 1.018 (1.009–1.028) | <0.001 | 1.017 (1.008–1.028) | <0.001 |
| Sex | 0.057 | |||
| Male | 1 | |||
| Female | 0.825 (0.677–1.006) | |||
| Tumor Size | 1.048 (0.998–1.100) | 0.060 | ||
| Tumor location | 0.584 | |||
| Colon | 1 | |||
| Rectum | 1.057 (0.868–1.286) | |||
| Differentiation | <0.001 | |||
| Well- moderate | 1 | |||
| Poor-undifferentiated | 2.221 (1.679–2.938) | |||
| pT category | <0.001 | <0.001 | ||
| T1 | 1 | 1 | ||
| T2 | 1.848 (0.571–5.988) | 1.566 (0.482–5.086) | ||
| T3 | 4.304 (1.376–13.469) | 2.102 (0.665–6.642) | ||
| T4 | 6.319 (2.018–19.788) | 2.994 (0.945–9.485) | ||
| pN category | <0.001 | <0.001 | ||
| N0 | 1 | 1 | ||
| N1 | 4.142 (3.266–5.252) | 3.460 (2.695–4.442) | ||
| N2 | 10.531 (8.076–13.732) | 9.096 (6.856–12.066) | ||
| pTNM stage | 0.001 | |||
| I | 1 | |||
| II | 1.979 (1.217–3.218) | |||
| III | 8.962 (5.697–14.099) | |||
| Neutrophil count | <0.001 | 0.093 | ||
| ≥3.61×109/L | 1 | 1 | ||
| <3.61×109/L | 0.682 (0.559–0.832) | 0.815 (0.642–1.034) | ||
| Lymphocyte count | 0.001 | 0.062 | ||
| ≥1.35×109/L | 1 | 1 | ||
| <1.35×109/L | 1.521 (1.190–1.945) | 1.308 (0.987–1.734) | ||
| Platelet count | 0.026 | |||
| ≥280×109/L | 1 | |||
| <280×109/L | 0.786 (0.635–0.972) | |||
| Albumin level | <0.001 | 0.002 | ||
| ≥34.6 g/L | 1 | 1 | ||
| <34.6 g/L | 1.779 (1.292–2.448) | 1.678 (1.203–2.341) | ||
| The total number of eLNs | 0.990 (0.981–1.000) | 0.041 | 0.984 (0.975–0.994) | 0.002 |
| Tumor deposits | 1.200 (1.165–1.237) | <0.001 | 1.102 (1.059–1.146) | <0.001 |
| PT | 1.042 (0.971–1.117) | 0.252 | ||
| APTT | 1.007 (0.992–1.022) | 0.367 | ||
| Fibrinogen level | <0.001 | 0.018 | ||
| ≥3.64 g/L | 1 | 1 | ||
| <3.64 g/L | 0.641 (0.525–0.782) | 0.777 (0.630–0.958) | ||
| NLR | <0.001 | 0.060 | ||
| ≥2.23 | 1 | 1 | ||
| <2.23 | 0.602 (0.496–0.730) | 0.789 (0.617–1.010) | ||
| PLR | <0.001 | |||
| ≥169.2 | 1 | |||
| <169.2 | 0.664 (0.535–0.824) | |||
| PNI | <0.001 | |||
| ≥41.1 | ||||
| <41.1 | 2.347 (1.609–3.425) | |||
Abbreviations: CI, confidence interval; HR, hazard ratio; eLNs, examined lymph nodes; PT, prothrombin time; APTT, activated partial thromboplastin time; NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte ratio; PNI, prognostic nutritional index.