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. 2020 Dec 23;13:13111–13119. doi: 10.2147/OTT.S275613

Table 3.

Univariate Analysis of Prognostic Factors in Patients with Nasopharyngeal Carcinoma

Variable Univariate Analysis
HR 95% CI P-value
Overall survival
 Age (>45 years vs ≤45 years) 1.61 1.34–1.94 <0.001
 Sex (Female vs Male) 0.74 0.59–0.93 0.010
 Smoking (Yes vs No) 1.41 1.17–1.69 <0.001
 Drinking (Yes vs No) 1.10 0.83–1.45 0.501
 Family history of cancer (Yes vs No) 0.86 0.69–1.06 0.147
 Serum calcium level (Low vs High) 1.33 1.10–1.61 0.003
 WHO type (II+III vs I) 0.48 0.18–1.29 0.146
 TNM stage (III–IV vs I–II) 2.94 2.20–3.93 <0.001
 Chemotherapy (No vs Yes) 2.12 1.51–2.96 <0.001
Disease-free survival
 Age (>45 years vs ≤45 years) 1.44 1.22–1.69 <0.001
 Sex (Female vs Male) 0.79 0.65–0.97 0.020
 Smoking (Yes vs No) 1.33 1.13–1.57 0.001
 Drinking (Yes vs No) 1.21 0.96–1.53 0.107
 Family history of cancer (Yes vs No) 0.83 0.69–1.00 0.046
 Serum calcium level (Low vs High) 1.23 1.05–1.45 0.012
 WHO type (II+III vs I) 0.49 0.20–1.18 0.113
 TNM stage (III–IV vs I–II) 2.24 1.78–2.82 <0.001
 Chemotherapy (No vs Yes) 1.68 1.28–2.19 <0.001
Distant metastasis-free survival
 Age (>45 years vs ≤45 years) 1.21 0.97–1.52 0.089
 Sex (Female vs Male) 0.65 0.48–0.86 0.003
 Smoking (Yes vs No) 1.47 1.17–1.83 0.001
 Drinking (Yes vs No) 1.23 0.89–1.69 0.203
 Family history of cancer (Yes vs No) 0.92 0.71–1.18 0.487
 Serum calcium level (Low vs High) 1.39 1.11–1.75 0.004
 WHO type (II+III vs I) 1.49 0.21–10.61 0.691
 TNM stage (III–IV vs I–II) 2.81 1.99–3.96 <0.001
 Chemotherapy (No vs Yes) 1.90 1.29–2.80 0.001
Relapse-free survival
 Age (>45 years vs ≤45 years) 1.19 0.93–1.52 0.177
 Sex (Female vs Male) 1.06 0.80–1.26 0.672
 Smoking (Yes vs No) 0.97 0.75–1.70 0.822
 Drinking (Yes vs No) 1.10 0.76–1.59 0.625
 Family history of cancer (Yes vs No) 0.77 0.57–1.03 0.076
 Serum calcium level (Low vs High) 0.93 0.72–1.19 0.540
 WHO type (II+III vs I) 0.25 0.09–0.68 0.006
 TNM stage (III–IV vs I–II) 1.54 1.13–2.11 0.007
 Chemotherapy (No vs Yes) 1.69 1.12–2.56 0.013

Note: P value was calculated using the univariate Cox proportional hazards model.

Abbreviations: WHO, World Health Organization; HR, hazard ratio; 95% CI, 95% confidence interval.