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. 2020 Dec 23;13:13131–13141. doi: 10.2147/OTT.S281095

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© 2020 Gong et al.

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miR-331-3p targets HDAC5 in NSCLC cells. TargetScan showed that the 3ʹUTR of HDAC5 included the complementary sites for miR-331-3p (A). Dual-luciferase reporter assay demonstrated detected the interaction between miR-331-3p and HDAC5 (B). RT-qPCR and Western blot were used to detect mRNA and protein levels of HDAC5 in A549 and CALU‐1 cells (C–E). **p < 0.01, miR-331-3p mimic compared with miR-NC mimic.