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Schematic model for histone arginine methylation and DNA repair process. Oxidative stresses induce the conversion of guanine (G) to oxidative guanine (8-oxoG), following which OGG1 can recognize 8-oxoG and recruit PRMT5 to the damaged site. Then, the tail of histone H4 near 8-oxoG is methylated to H4R3me2s by PRMT5. H4R3me2s can increase DNA repair efficiency through binding with FEN1 and enhancing FEN1 activity.
