Table 3.
Extracellular ROS induce intracellular ROS generation and promote different signaling and functions.
| ROS | Target | Concentration | Function | PMID | Ref # | |
|---|---|---|---|---|---|---|
| ONOO- | Increase | 100uM | Angiogenesis | 18309287 | [192] | |
| Increase | Apoptosis | 9020024 | [218] | |||
| H2O2 | Increase | 1-4uM | Insulin secretion | 17400930 | [70] | |
| Increase | NOX4 | 10 uM | Proliferation, Migration | 25315297 | [191] | |
| Increase | 10-20uM | Proliferation | 15109912 | [193] | ||
| Increase | Cyto/Nuc ROS | 50uM | Nuclear Calcium signaling | 20393594 | [71] | |
| Increase | 100uM | 26461342 | [142] | |||
| Increase | 200uM | Apoptosis | 29061494 | [187] | ||
| Increase | 300uM | Tumor progression | 18801366 | [198] | ||
| Increase | 1 mM | Caspase-independent apoptosis | 20084055 | [69] |