Table 4A.

Eight cytokines, four growth factors, three out of four hormone/neurotransmitters promote ROS production, and anti-inflammatory cytokines IL-10 and Il-35 inhibit ROS production. IGF-1, NE and Dopamin also decrease ROS production in certain condition.

		ROS	Sensor	Target	Concentration	Function	PMID	Ref#
Cytokine	TNF-α	Increase	TNFR	5-lipoxygenase	10 ng/ml	Inflammation	10934206	[72]
		Increase	TNFR1	Complex II, ΔΨm	20 ng/ml	Inflammation, Apoptosis	17765224, 20203691	[78,117]
	IFN-γ	Increase	IFN-γR	Complex II/NOX	20 U/ml	Inflammation	17765224	[78]
		Increase	IFN-γR	Duox2	100 U/mL	Innate immunity	16111680	[174]
	TGF-β	Increase	TGFBR	NOX, Complex I	10 ng/ml	Fibronectin secretion/EMT	15677311	[245]
		Increase	TGFBR	NOX4	50 ng/ml	Angiogenesis	25315297	[191]
	IL-1	Increase	IL1R		10 ng/ml	Angiogenesis	26811540	[173]
		Increase	IL1R	NOX	20 ng/ml	Inflammation	17765224	[78]
	IL-2	Increase	IL2R		100 U/ml	Angiogenesis	18309287	[192]
	IL-4	Increase	IL4R	Duox1	10 ng/ml	Inflammation, Innate immunity	16249002, 16111680	[174,206]
	IL-13	Increase	IL13R	Duox1	10 ng/ml	Innate immunity	16111680	[174]
		Increase	IL13R	NOX	1 μg/μl	Cell death/damage	19752235	[175]
	IL-27	Enhance	IL27R	NOX2	100 ng/ml	Inflammation	28240310	[79]
	IL-10	Decrease	IL10R		10 ng/ml	Inhibit endothelial cell activation	31731100	[146]
	IL-35	Decrease	IL12R/IL27R	Mt	10 ng/ml	Inhibit endothelial cell activation	29371247, 31731100	[146,208]
Growth factor	EGF	Increase	EGFR		5 ng/ml	Adhesion, Migration, Proliferation	19635476	[209]
		Increase	EGFR	NOX	10 ng/ml	Proliferation	25122478	[188]
		Increase	EGFR		40 ng/ml	Angiogenesis	17045920	[194]
		Increase	EGFR		100 ng/ml	Necrosis	10854274	[73]
	PDGF	Increase	PDGFR		1 ng/ml	Proliferation	15109912	[193]
		Increase	PDGFR		15 ng/ml	Senescence	16081426	[220]
		Increase	PDGFR		20 ng/ml	Inflammation	23774581	[246]
	VEGF	Increase	VEGFR	mtROS	50 ng/ml	Migration	31653897	[143]
	IGF-I	Decrease	IGF-1R		100 ng/ml	Survival	20084055	[69]
		Increase	IGF-1R	NOX4	200 ng/ml	Migration	18567639	[210]
Hormone/Neurotransmitter	NE	Decrease			10uM	Protect DNA damage	26167254	[185]
	Insulin	Enhanced	IR		10–100 nM	Enhance insulin sensitivity	19808019	[183]
	Dopamine	Increase		MAO	0-50uM	Physiological signaling	20547771	[67]
		Increase		mtROS (SOD)	1uM	Physiological signaling	23994527	[68]
		Increase		MAO	100μM, 500uM	Cell death	20547771	[67]
		Decrease	D5R	NOX		Protect from hypertension	23425954	[186]
	Serotonin	Increase	5-HT1BR	NOX1	1uM	Post-translational oxidative modification of protein, proliferation	28473438	[247]
					10-100uM	Caspase-3 dependent apoptosis	16286591	–
	AngII	Increase	AT1R	NOX4 (Nuc/Cyto)	1 nM	Gene regulation, Protect from cell damage	19409874, 19948986	[169,176]
		Increase	AT1R	NOX	100 nM	maintain arterial tone	29472601	[177]
		Increase	ET-1AR	NOX	100 nM	Proliferation	14642698	[178]
		Increase	AT1/2R	NOX	100 nM	Apoptosis, Necrosis, Senescence	12606818, 21270817	[179,180]
		Increase	AT1R	NOX	1uM	Impair insulin signaling	16982630	[181]