Supplemental table 1.
The 41 enzymes which are regulating superoxide and hydrogen peroxide are actively functioned and regulated in metabolic processes.
| Namec | Abbreviation | Function |
|---|---|---|
| Aldehyde oxidase | AOX1 | Valine, leucine and isoleucine degradation, Tyrosine metabolism, Tryptophan metabolism, Vitamin B6 metabolism and Nicotinate and nicotinamide metabolism |
| Amine oxidase (flavin- containing) A | AOFA | Deamination of 5-hydroxytryptamine, norepinephrine and epinephrine. |
| Amine oxidase (flavin- containing) B | AOFB | Deamination of benzylamine and phenylethylamine |
| d- Amino acid oxidase | OXDA | Regulate the level of neuromodulator d-serine and dopamine synthesis |
| l- Amino acid oxidase | OXLA | Lysosomal antigen processing and presentation |
| d- Aspartate oxidase | OXDD | Deamination of d-aspartate and its N-methylated derivative, N-methyl d-aspartate |
| Amiloride- sensitive amino oxidase (copper containing) | AOC1 | Degradation of putrescine, histamine, spermine and spermidine |
| Cytochrome P450 3A4 | CP3A4 | Metabolism of sterols, steroid hormones, retinoids and fatty acids |
| Cytochrome P450 2D6 | CP2D6 | Metabolism of fatty acids, steroid and retinoids |
| Cytochrome P450 2E1 | CP2E1 | Metabolism of saturated fatty acids and xenobiotics |
| Cytochrome P450 4A11 | CP4AB | Metabolism of fatty acids and their oxygenated derivatives (oxylipins) |
| ERO1- like protein- α | ERO1A | Involved in disulfide bond formation in ER and reoxidizes P4HB/PDI |
| ERO1- like protein- β | ERO1B | Involved in disulfide bond formation in ER and reoxidizes P4HB/PDI |
| FAD- linked sulfhydryl oxidase ALR | ALR | Regenerate the redox-active disulfide bonds in CHCHD4/MIA40 |
| Hydroxyacid oxidase 1 | HAOX1 | Active on 2-carbon substrate glycolate and 2-hydroxy fatty acids |
| Hydroxyacid oxidase 2 | HAOX2 | Oxidation of L-alpha-hydroxy acids and L-alpha-amino acids |
| Membrane primary amine oxidase | AOC3 | Semicarbazide-sensitive (SSAO) monoamine oxidase activity |
| Peroxisomal N1- acetylspermine/spermidine oxidase | PAOX | Oxidation of N1-acetylspermine to spermidine and putrescine, and polyamine back-conversion |
| Peroxisomal acyl- CoA oxidase 1 | ACOX1 | Desaturation of acyl-CoAs to 2-trans-enoyl-CoAs |
| Peroxisomal acyl- CoA oxidase 3 | ACOX3 | Oxidizes the CoA-esters of 2-methyl-branched fatty acids |
| Peroxisomal sarcosine oxidase | SOX | Metabolizes sarcosine, l-pipecolic acid and l-proline |
| Prenylcysteine oxidase 1 | PCYOX | Degradation of prenylated proteins and cleavage of thioether bond of prenyl-l-cysteines |
| Prenylcysteine oxidase- like | PCYXL | Prenlcysteine oxidase activity |
| Protein- lysine 6- oxidase | LYOX | Post-translational oxidative deamination of peptidyl lysine residues and regulate Ras expression |
| Pyridoxine 5′- phosphate oxidase | PNPO | Oxidation of pyridoxine 5′-phosphate and pyridoxamine 5′-phosphate |
| Retina- specific copper amine oxidase | AOC2 | Oxidation of 2-phenylethylamine and tryptamine |
| Spermine oxidase | SMOX | Oxidation of spermine and metabolism of N1-acetylspermine and spermidine |
| Sulfhydryl oxidase 1 | QSOX1 | Oxidation of sulfhydryl groups in peptide and protein thiols |
| Sulfhydryl oxidase 2 | QSOX2 | Oxidation of sulfhydryl groups in peptide and protein thiols |
| Sulfite oxidase, mitochondrial | SUOX | Metabolism of sulfur |
| Xanthine dehydrogenase/oxidase | XDH | Purine degradation; oxidation of hypoxanthine and xanthine |
| NADPH oxidase 1 | NOX1 | Regulate cellular pH and mediate proton currents |
| NADPH oxidase 2 | NOX2 (CY24B) | Regulate cellular pH and mediate proton currents |
| NADPH oxidase 3 | NOX3 | Biogenesis of otoconia/otolith |
| NADPH oxidase 4 | NOX4 | Inhibit phosphatase and regulate KCNK3/TASK-1 patassium channel |
| NADPH oxidase 5 | NOX5 | calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa |
| Dual oxidase 1 | DUOX1 | Synthesis thyroid hormone, contribute to thyroid peroxidase/TPO and lactoperoxidase/LPO activity |
| Dual oxidase 2 | DUOX2 | Synthesis thyroid hormone, contribute to thyroid peroxidase/TPO and lactoperoxidase/LPO activity |
| Superoxide dismutase [Cu–Zn] | SOD1 | Form fibrillar aggregates in the absence of intramolecular disulfide bond |
| Superoxide dismutase [Mn], mitochondrial | SOD2 | Transcription of RNA polymerase Ii and release of cytochrome C |
| Extracellular superoxide dismutase [Cu–Zn] | SOD3 | Response to copper ion and hypoxia |
c
The 41 enzymes are generated from PMID:32231263 [102]. The function of enzymes are collected from Human metabolome database (https://hmdb.ca/) and Uniport database (https://www.uniprot.org/).