Supplemental table 3.

ROS generation Inhibitors.

	Target	Drug	Cell type	Concentration	PMID	Ref #
General ROS		NAC	RPE cell	1 mM	17765224	[78]
			Epithelial cell	30 mM	15109912	[193]
			Fibroblast	20 mM	16081426	[220]
			INS-1 cell	0.4 mM	17400930	[70]
		PDTC	RPE cell	50uM	17765224	[78]
		Vitamin C	Endothelial cell	10uM	10828488	[278]
		Vitamin E	Endothelial cell	10uM	10828488	[278]
		Tempol	Astrocyte	3 nM	21270817	[180]
		MnTBAP	Astrocyte	50uM	20547771	[67]
Mitochondrial ROS	complex I	rotenone	RPE cell	2.5uM	17765224	[78]
			NIH-3T3 fibroblast	5uM	12796479	[204]
	complex II	TTFA	RPE cell	10uM	17765224	[78]
		Atpenin A5	Cardiomyocyte	100 nM-1uM	19242645	[279]
		Malonate	Heart Mt	25-100uM	18433712	[280]
	Complex III	Myxothizol	Liver Mt	0.56 mg/kg	24661880	[281]
		Antimycin A	hepa1-6,Huh-7 cell	1ug/ml	26461342	[142]
			RPE cell	100 ng/ml	17765224	[78]
	Compled IV	Sodium azide	Motoneurone	2 mM	14660707	[282]
	ATPase	Oligomycin			20107899	[283]
	Non-selective	Mito-Tempo	HAEC	1 mM	27127201	[60]
	Non-selective	Mito-Vit-E	HUVEC	1uM	31653897	[143]
NOS	Non-selective	l-NAME	L6 myotube	1 mM	16982630	[181]
	nNOS	NOSIP			19298861	[89]
	eNOS	NMMA			28904082	[284]
NOX	Non-selective	apocynin	SMC	50uM	29472601	[177]
			VSMC	100uM	23774581	[246]
		DPI	RPE cell	5uM	17765224	[78]
			Endothelial cell	15uM	16249002	[206]
			HT-29 cell	10uM	25122478	[188]
			Fibroblast	20uM	16081426	[220]
			NIH-3T3 fibroblast	5uM	12796479	[204]
		AEBSF		0.9uM	23251382	[285]
	NOX1	ML171	SMC	1uM	29472601	[177]
	NOX1/4	GKT136901			24319690	[286]
LOX		NDGA	Epithelial cell		19635476	[209]
			NIH-3T3 fibroblast	10uM	12796479	[204]
MPO		ABAH			23251382	[285]
MAO		Selegiline	Astrocyte	20uM	20547771	[67]

NAC– N-acetyl-l-cysteine, PDTC– pyrrolidene-dithiocarbamate, MnTBAP– Manganese III tetrakis, TTFA– 2-thenoyltrifluoroacetone,l-NAME—N omega-Nitro-l-arginine methyl ester hydrochloride, NMMA– NG-monomethyl-arginine, NOSIP– nitric oxide synthase interacting protein, DPI– diphenylene iodonium, SEBSF– 4-(2-aminoethyl)-benzenesulfonyl fluoride, NDGA– nordihydroguaiaretic acid, ABAH– 4-aminobenzoic acid hydrazide.