Supplemental Table 4.
The targets in various treatments in Figure 4 (MitoETC and membrane potential, NOX, SOD and LOX) and genes of their downstream pathways are analyzed by circus plot (see details in Fig. 2A and b).
| Target | Mitochondria ETC and membrane potential | NOX | SOD | LOX |
|---|---|---|---|---|
| Downstream signaling genes | ROMO1 | CDK5 | MAPK3 | PTK2 |
| BCL2L1 | MAPK1 | MAPK1 | PLA2G4A | |
| CASP3 | MAPK2 | |||
| CASP8 | MAPK3 | |||
| NFKB1 | NOS3 | |||
| MAPK1 | PIK3CB | |||
| MAPK2 | AKT1 | |||
| MAPK3 | HMOX1 | |||
| RAC1 | NFKB1 | |||
| AKAP1 | MMP2 | |||
| UTRN | MMP9 | |||
| OPA1 | PRRT2 | |||
| NLRP3 | CDKN2A | |||
| PYCARD | IRS1 | |||
| CASP1 | NFE2L2 | |||
| NOS2 | ||||
| MAP1LC3A | ||||
| PTK2 | ||||
| STAT3 | ||||
| VEGFA | ||||
| MAPK3 | ||||
| MAPK1 | ||||
| CTNNB1 | ||||
| CDK2 | ||||
| MAPK8 | ||||
| MAP2K7 | ||||
| VCAM1 | ||||