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. 2020 Dec 23;12:13173–13184. doi: 10.2147/CMAR.S286275

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© 2020 Shi et al.

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Identifying EGFR as the target of METTL14 in HCC. (A) Analysis of RNA-sequencing and m6A-sequencing data of METTL14 knockdown in HepG2 cells deposited in GSE90642. (B) KEGG analysis of the potential targets of METTL14 in HCC. (C) PPI analysis and the top 10 hub genes of the potential targets of METTL14. (D) METTL14 knockdown resulted in downregulated m6A levels but upregulated mRNA levels of EGFR in GSE90642. (E) The m6A peak in EGFR mRNA. (F and G) qPCR and Western blot analysis showed that METTL14 knockdown increased EGFR expression. (H) Western blot analysis showed that YTHDF2 knockdown increased EGFR expression. **p<0.01; ***p<0.001.