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Blockade of shh signaling pathway reversed the effect of CH1 on neurological outcomes. (A and D) Sensorimotor functions were once again assessed before (baseline) and up to 28 days in the absence or presence of CYC by the rotarod (A), mNSS evaluation (B) and adhesive removal test (C and D). (E and F) Representative Western blot images (E) and quantitative data (F) of GAP43 in the absence or presence of CYC. *P< 0.05, **P< 0.01 by one-way ANOVA, n =5–6 mice per group.
