qPCR analysis in HUVECs of COX-2 mRNA induction by CGP42112A or Ang II stimulation.
(A), (B) CGP42112A (10−8 M) upregulated COX-2 mRNA significantly under siControl-N (A) or siControl-C (B) compared to siATIP-N or siATIP-C, respectively (ANOVA, *p < 0.05). The significance between each treatment on the Post Hoc test at the indicated hour is shown (*p < 0.05). (C) Ang II (10−7 M) upregulated COX-2 mRNA, which was suppressed by knocking down siATIP-C (*p < 0.05). Values are the mean ± SEM for all three experiments.