Fig. 8.

Different plots have been analyzed by using prognoscan server: (a) Expression plot: Patients are ordered in terms of CSN1S1 expression values. The cumulative number of patients are plotted against the expression value. The optimal cut points are shown by the straight lines (cyan) in which patients are separated into high (red) and low (blue) expression groups. (b) Expression histogram: The distribution of the expression value is presented where the X-axis represents the number of patients and the Y-axis represents the expression value on the same scale as the expression plot. The optimal cutpoint line (cyan) is also present. (c) p-value plot: Calculations are done on patients regarding survival difference between high and low expression groups. The X-axis indicates the cumulative number of patients on the same scale as the expression plot where the raw P-values (log scale) is presented in Y - axis. The cutpoint to minimize the P-value which is determined and indicated by the cyan line. The gray line indicates the 5% significance level. (d) Survival Plot: The events (relapse, progression, death) may not be observed for some individuals within the study time period, producing censored observations. The X-axis represents the cumulative number of patients while Y-axis represents the study time. The cut point is indicated by the cyan line. (e) Attribute plot: Patients are separated based on grade and Receptor Expression. The X-axis represents the cumulative number of patients on the same scale as the expression plot whereas the Y-axis represents parameters based on which we mentioned. The cut point is indicated by the cyan line. (f) Kaplan-Meier plot: Survival curves for high (red) and low (blue) expression groups are separated at the optimal cut point. Times are plotted against the survival rate. 95% confidence intervals for each group are also indicated by dotted lines. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)