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. 2020 Dec 14;11:581699. doi: 10.3389/fphys.2020.581699

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Copyright © 2020 Gong, Lyu, Shi, Zou, Lu, Yang and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Volcano plots of serum metabolites. (A) Shows the D7 group compared to the D0 group. (B) Shows the D25 group compared to the D7 group. (C) Shows the D25 group compared to the D0 group. The red dots represent metabolites that are up-regulated, the blue dots represent metabolites that are down-regulated, and the gray dots represent metabolites that do not change significantly. The dot sizes indicate the variable importance in the projection (VIP) value. D0, overfeeding for 0 day; D7, overfeeding for 7 days; D25, overfeeding for 25 days.