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. 2020 Dec 14;11:594841. doi: 10.3389/fimmu.2020.594841

Figure 1.

Figure 1

Genomic landscape of Richter syndrome. Genes recurrently mutated and related cellular functions altered in RS as a manually curated heat map of available data from 4 landmark papers, gathering a total of 207 RS patients. From left to right (for each gene): gene name, functional annotations and related pathways (according various databases and literature), cytogenetic band, nature of the reported abnormality (deletion, gain, translocation, or single nucleotide variant) and full gene name written according to a color-code indicating biotype (black: protein coding gene; red: miRNA and blue: lncRNA). Selection thresholds: 5% occurrence in cohorts of at least 50 samples for CNVs and 10 samples for SNPs. BCR, B-cell Receptor; CNV, Copy Number Variation; GPCR, G Protein-Coupled Receptor; lncRNA, Long Non-Coding RNA; MAPK, Mitogen-Activated Protein Kinase; miRNA, MicroRNA; NS, Nervous System; RS, Richter Syndrome; RTK, Receptor Tyrosine Kinase; SNP, Single Nucleotide Polymorphism; TGF, Transforming Growth Factor; TNF, Tumor Necrosis Factor.