Table 3.

Summarized details of the final shortlisted drug target candidates for dormant Mtb.

Gene ID	Gene name	Protein name	Function	Protein length	Gene expression status	Network properties
Rv2590	fadD9	Probable fatty-acid-CoA ligase FadD9 (Fatty-acid-CoA synthetase)	Involved in lipid degradation, specific function unknown	1168	Upregulated two-to four-folds in all dormancy models	Neighbors: 4, DEG among neighbors: 1
Rv3515c	fadD19	Long-chain-fatty-acid-CoA/3-oxocholest-4-en-26-oate-CoA ligase	Involved in the activation of long-chain fatty acids as acyl-coA and cholesterol degradation	548	Upregulated two to seven-folds in all dormancy models	Neighbors: 1, DEG among neighbors: 1
Rv1832	gcvB	Probable glycine dehydrogenase (decarboxylating)	Component of glycine cleavage system, binds to the α-amino group of glycine	941	Upregulated 3-8 folds in 3 dormancy models	Neighbors: 18, DEG among neighbors: 9
Rv2780	ald	Alanine dehydrogenase	Catalyzes reversible reductive amination of pyruvate to L-alanine, functions as a homohexamer	371	Upregulated 4- to 40-folds in 3 dormancy models	Neighbors: 105, DEG among neighbors: 39
Rv1994c	cmtR	HTH-type transcriptional regulator (CmtR)	Metal-dependent repression of cmt operon promoter, functions as a homodimer	118	Upregulated 1.5- to 17-folds in all dormancy models	Neighbors: 241, DEG among neighbors: 103
Rv0324	Rv0324	Possible transcriptional regulatory protein (Possibly ArsR-family)	Possible transcriptional regulator, specific function unknown	226	Upregulated 1.5- to 3-folds in 3 dormancy models	Neighbors: 26, DEG among neighbors: 14