Figure 1.

Schematic illustration of the experimental design, kinetics of bodyweight, lesion weight, and hotplate latency of the two groups of mice in Experiment 1. (A) Schematic illustration of the experimental design. The yellow circles represent the injection of the mock isotype antibody for the anti-platelet antibody, and the blue circles represent the injection of anti-platelet antibody. Seven mice from each group were sacrificed 1 and 2 weeks after induction, respectively. Ten mice from each group were sacrificed 5 weeks after induction. One mouse in the PD group died of internal bleeding at 1 week after induction. (B) Kinetic changes in mean bodyweight. (C) Kinetic changes in mean lesion weight. (D) Kinetic changes in mean hotplate latency. The values show the means ± SDs. ^#0.05 < p = 0.053; *p < 0.05; NS: not statistically significant (p > 0.05) for the difference between the testing group and the Control group (by Wilcoxon’s test). PD, platelet depletion; Ab, antibody.