Table 1.
Studies according to the chromosome and the physical location of susceptible locus in the chromosome.
| Chromosome no. | Chromosomal location of loci | STR/SNP marker | Authors |
|---|---|---|---|
| 1 | 1q24-25 | Hereditary PCA 1 (HPCA1) | 41 |
| 19 | Prostate-specific antigen (PSA) gene is located at the 19q13.41 chromosome 19 | the A/G polymorphism at the ARE I the promoter region of the PSA gene | 3 |
| X | Xq11Xq13 Region | PGK1 STR Allele | 39 |
| Xq11-12 in exon 1 of the AR gene | Polymorphic CAG repeats in exon 1. | 19 | |
| Xq11-12 in exon 1 of the AR gene | CAG and GGC repeats | 72 | |
| In the exon 1 of the androgen receptor (AR) gene at the Xq11.2-q12 chromosome X. | CAG and GGC repeats | 3 | |
| In the exon 1 of the androgen receptor (AR) gene at the Xq11.2-q12 chromosome X. | Polymorphic CAG repeat in the androgen receptor (AR). | 9 | |
| Y | DYS19 | DYS19 | 58 |
| four haplogroups DE, O2b*, O2b1, and untagged | four haplogroups DE, O2b*, O2b1, and untagged | 16 | |
| M253, M223, M46 (Tat), M17, and M269. M46 failed in genotyping | I1a*, R1a1, N3 K* P* R1a*, R1b3, I1c, |
32 | |
| Region Yp11.2 (DYS393, DYS456, DYS458 and DYS19) | Allele 12 of DYS393 and allele 19 of DYS458 (protective). Allele 13 of DYS393 (increased risk). |
12 | |
| Y-chromosome | Y-linked STR MultiPlex PCAR, DYS388, DYS435, DYS437, DYS439 | 36 | |
| 34 binary Y chromosome markers (the E1b1b1c haplogroup in the last intron of the taxilin gamma 2 pseudogene (TXLNG2P) on chromosome Yq11.222) | 34 chromosome Y markers genotyped, 26 were observed, and 28 haplogroups including three combined groups (R1b1b + R1b*, R1a + R1*, and I2b + I2c), as the leaf nodes of the NRY tree | 45 | |
| Y-chromosome | 17 Y-STR (A commercial kit Y filer™ PCR amplification kit (Applied Biosystems, Foster City, CA). | 75 |
NRY, nonrecombining Y; STR, short tandem repeat; SNP, single-nucleotide polmorphism; PCR, polymerase chain reaction; CAG, nucleotides sequence; GGC, nucleotides sequence; AR, androgen receptor.