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. 2020 Dec 14;11:609697. doi: 10.3389/fendo.2020.609697

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Copyright © 2020 Ran, Zhou, Oda, Yasue, Abe, Ye, Li, Sasaoka, Sakimura, Ajioka and Saijo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo thyroid functionality assessment in adult Fgf10 Ex1^mut/Ex3^mut chimeric mice complemented with mouse embryonic stem cells (mESCs). (A) Immunofluorescence staining of the thyroids. Thyroid follicles were analyzed by staining for GFP (green) and markers of thyroid function. Tg, thyroglobulin; T3, tri-iodothyronine. Insets show magnified views of the areas indicated with white dotted lines. The right panels show magnified views of the areas indicated by dotted lines in the left panels. Nuclei were stained with DAPI (blue). Fgf10 ^wild/_wild and Fgf10 Ex1^wild/Ex3^mut chimeric mice served as controls. Scale bar = 50 μm. (B) ELISA analyses of serum tri-iodothyronine (T3) and thyroxine (T4) concentrations in adult Fgf10 Ex1^mut/Ex3^mut chimeric mice. Adult Fgf10 ^wild/_wild and Fgf10 Ex1^mut or Ex3^mut chimeric mice served as controls. Data are expressed as the means ± standard deviations; n = 3 for the adult Fgf10 Ex1^mut/Ex3^mut chimeric mouse group and n = 4 for the adult Fgf10 ^wild/_wild and Fgf10 Ex1^mut or Ex3^mut chimeric mouse groups; *p > 0.05 versus other treatments.