FIGURE 1.
Fisetin (FIS) alleviated bleomycin (BLM)-induced pulmonary fibrosis in mice. On day 7 after BLM treatment (2.5 mg/kg), mice were intragastrically administered with FIS (100 mg/kg) once every other day for 3 weeks. Mouse lungs were collected on day 28 after BLM treatment. The body weight (A), survival rate (B), lung wet-to-dry weight ratio (C), and hydroxyproline content (G) in lungs were determined. The representative images of HE-stained (×100 and ×200 magnification) and Masson’s trichrome-stained (×200 magnification) lung sections in mice (D) and comparisons of the inflammation score (E) and fibrosis score (F) between the experimental groups were shown. Data were presented as the means ± SD. * p < 0.05, ** p < 0.01. NS, non-significant.