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. 2020 Dec 14;7:609806. doi: 10.3389/fmolb.2020.609806

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Copyright © 2020 Gu, Al Dubayee, Alshahrani, Masood, Benabdelkamel, Zahra, Li, Abdel Rahman and Aljada.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IR metabolic model based on the positively identified features. (A) A Venn diagram showing that out of 3633 detected features, only 305 (^~8%) metabolites were positively identified. 43 (G43) significant metabolites were considered a metabolic pattern for IR, where they were statistically significant between lean vs obese and lean vs T2D, and insignificant between obese vs T2D (FDR-corrected p-value < 0.05). (B) A Venn diagram showing the number of the up- and down-regulated metabolites after fold change analysis (cutoff l.5) on the significant metabolites (G43) (nine and 18 metabolites, respectively). (C) The expression profile of G18 and (D) G9 metabolites.