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. 2020 Dec 14;7:609806. doi: 10.3389/fmolb.2020.609806

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Copyright © 2020 Gu, Al Dubayee, Alshahrani, Masood, Benabdelkamel, Zahra, Li, Abdel Rahman and Aljada.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Depicted top scoring I PA metabolomic networks. (A) “Cell-to-cell signaling and interaction, molecular transport, small molecule biochemistry “for IR metabolomic panel and (B) “cellular compromise, lip id metabolism, small molecule biochemistry” for T2DM metabolomic panel. The dotted lines indicate indirect and the straight lines indicate direct relationships. Nodes colored red represent up-regulation and green represent down-regulation. The interaction networks were generated through the use of IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis/).