Table 2.
Number of genes of the complement system found in ray-finned fishes.
| C1Q(A, B, C) | C2,C2/CFB | C4 | C3 | C5 | C6 | C7 | C8(α, β, δ) | C9 | CFH members | |
|---|---|---|---|---|---|---|---|---|---|---|
| Human | 3 | 2 | 2 | 1 | 1 | 1 | 1 | 3 | 1 | 1 |
| Spotted gar | 3 | 2 | 1 | 3 | 1 | 1 | 1 | 3 | 1 | 1 |
| Amazon molly | 2 (A, C) | 2 | 2 | 7 | 1 | 2 | 2 | 3 | 1 | 1 |
| Cavefish | 3 | 3 | 2 | 3 | 1 | 1 | 2 | 3 | 1 | 5 |
| Cod | 3 | 2 | 4 | 4 | 1 | 1 | 2 | 2 (α, β) | 2 | 3 |
| Fugu | 3 | 2 | 1 | 5 | 1 | 1 | 2 | 3 | 1 | 2 |
| Medaka | 3 | 2 | 2 | 5 (1) | 1 | 1 | 2 | 3 | 1 | 2 |
| Platyfish | 3 | 2 | 1 | 5 | 1 | 1 | 2 | 3 | 1 | 3 |
| Stickleback | 1 (C) | 2 | 1 | 5 (3) | 1 | 1 | 2 | 3 | 1 | 3 |
| Tetraodon | 3 | 2 | 2 | 4 | 1 | 1 | 2 | 3 | 1 | 4 |
| Tilapia | 3 | 2 | 2 | 5 | 1 | 1 | 2 | 3 | 1 | 4 |
| Zebrafish | 3 | 4 | 2 | 8 | 1 | 2 | 2 | 3 | 1 | 6 |
| Sea bass | 3 | 2 | 2 | 4 (10) | 1 | 1 | 2 | 3 | 1 | 2 |
| Sea bream | 3 | 2 | 1 | 9 | 1 | 1 | 2 | 3 | 1 | 4 |
The identified human gene copies are indicated for comparison. The number of incomplete C3 genes found in teleost genomes is indicated within brackets. Searches included the genes of the three chains of C1Q (A, B, C) and of C8 (α, β, δ). Phylogenetic trees for the fish C1q, C2/Cfb, C6, C7, C8, and C9 are available in Supplementary Figure 1 .